From Comic Book Movie:
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“As far as I know, I’m done,” Portman said during the video interview. “I don’t know if, maybe, one day they’ll ask for an Avengers 7 or whatever. I have no idea! But as far as I know I’m done.” She then said that her overall experience playing Jane Foster “was all great” and that she’s thankful to have been a part of the ever-growing shared universe.