From Entertainment Weekly:
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Star Ryan Reynolds, who is EW’s Entertainer of the Year, is about to return to the red leather suit as mercenary Wade Wilson for the highly anticipated sequel. “We’re just in the development stage but we’re about to move into production,” he says. Reynolds confirms that they’re currently casting for Cable and “we’re looking at” telekinetic female merc Domino as another character for the sequel.
But all has not been smooth sailing: the first film’s director, Tim Miller, recently departed the project due to reported “creative differences.” Of Miller, Reynolds tells EW, “There is not a human being on earth that worked harder on Deadpool than Tim. He’s an incredibly, incredibly talented director.”